LENTIVIRUSES FOR CELL IMMORTALIZATION

We offer premade recombinant lentiviruses expressing SV40 large and small T antigens, MycRas, Bmi1 and CDK4 genes, HPV16 E6/E7 protein, as well as siRNA against p53 and Rb.

 

 

 

 

 

 

                                                                                                                                                  

Viral genes, including Simian virus 40 (SV40) T antigen, Epstein Barr virus (EBV), Adenovirus E1A and E1B, and human Papilomavirus (HPV) E6 and E7 can induce immortalization in different cell types. SV40 T antigen has been shown to be the most simple and reliable agent for the transformation of many different cell types in culture. The mechanism of SV40 T antigen in cell immortalization is well studied. For the most part, viral genes achieve immortalization by inactivating the tumor suppressor genes (p53, Rb and others) that can induce a replicative senescent state in cells. Recent studies have also shown that SV40 T antigen can induce Telomerase activity in the infected cells.

 

 

ORDERS : Online

By Email: orders@capitalbiosciences.com

By Fax: 240-363-0739

Technical Inquiries:

Please note: we take all technical inquiries by email. Email your questions to TechSupport and receive a detailed response within 24 hours.

Billing, Sales, Customer Support:                     1-800-475-2812

sign up for our Newsletter