We offer variety of ready-to-use recombinant lentivirus vectors for labeling mammalian cells with different fluorescent and chemiluminescent reporters, a well as vectors for primary cells immortalization and cell reprogramming. Lentiviral vectors are powerful tools for delivery of a gene of interest (GOI) into target cells. In contrast with murine retrovirus-derived vectors, lentivirus can infect both dividing and non-dividing mammalian cells. The GOI is integrated into the host genome allowing stable long-term gene expression in vitro and in vivo.
Single and Dual Reporter lentiviruses express fluorescent proteins such as CFP, GFP, RFP and YFP, as well as bioluminescent marker Luciferase derived from different sources.
Lentiviruses for primary cells immortalization include vectors with SV40 T antigens, HPV16 E6/E7 fusion protein and various oncogenes. For immortalization of B-cells we offer EBV.
Lentiviruses for iPSC include vectors with genes that cause cell reprogramming.
For safety issues related to recombinant lentiviruses please refer to the guidance documents available at the site of Office of Biotechnology Activities (NIH) here.