Adenovirus Production

Recombinant adenoviruses are a versatile and highly efficient tool used for gene delivery and expression in mammalian cells. A number of biological features of adenovirus have made such viruses the vectors of choice for both in vitro and in vivo applications. Adenoviruses can infect a broad range of cell types with the highest efficiency and infection is not dependent on active host cell division. A second key feature is that high virus titers and high-level gene expression can be obtained in most mammalian cells.

A recombinant adenovirus containing full-length cDNA will allow high level gene expression in host cells, whereas adenovirus construct containing RNAi oligoes specific to a target gene will generate efficient elimination of target gene expression.